| 20/09/2018 |
| AEK Larnaca - Zurich | 0-1 |
| Ludogorets - Leverkusen | 2-3 |
| Leipzig - Red Bull Salzburg | 2-3 |
| Celtic Glasgow - Rosenborg | 1-0 |
| Copenhagen - Zenit St. Petersburg | 1-1 |
| Slavia Prague - Bordeaux | 1-0 |
| Spartak Trnava - Anderlecht | 1-0 |
| Dinamo Zagreb - Fenerbahce | 4-1 |
| Sporting Portugal - Qarabag | 2-0 |
| Arsenal - Vorskla | 4-2 |
| F91 Dudelange - Milan | 0-1 |
| Olympiakos - Betis Sevilla | 0-0 |
| Villarreal - Glasgow Rangers | 2-2 |
| Rapid Wien - Spartak Moscow | 2-0 |
| Marseille - Frankfurt | 1-2 |
| Lazio - Apollon Limassol | 2-1 |
| Genk - Malmö | 2-0 |
| Besiktas - Sarpsborg 08 | 3-1 |
| Akhisar Belediyespor - Krasnodar | 0-1 |
| Sevilla - Standard | 5-1 |
| Rennes - Jablonec | 2-1 |
| Dynamo Kiev - Astana | 2-2 |
| PAOK Thessaloniki FC - Chelsea | 0-1 |
| Videoton - Bate Borisov | 0-2 |
