| 13/12/2018 |
| Villarreal - Spartak Moscow |
| Rapid Wien - Glasgow Rangers |
| Marseille - Apollon Limassol |
| Lazio - Frankfurt |
| Besiktas - Malmö |
| Genk - Sarpsborg 08 |
| Sevilla - Krasnodar |
| Akhisar Belediyespor - Standard |
| Rennes - Astana |
| Dynamo Kiev - Jablonec |
| PAOK Thessaloniki FC - Bate Borisov |
| Videoton - Chelsea |
| AEK Larnaca - Leverkusen |
| Ludogorets - Zurich |
| Leipzig - Rosenborg |
| Celtic Glasgow - Red Bull Salzburg |
| Copenhagen - Bordeaux |
| Slavia Prague - Zenit St. Petersburg |
| Spartak Trnava - Fenerbahce |
| Dinamo Zagreb - Anderlecht |
| Sporting Portugal - Vorskla |
| Arsenal - Qarabag |
| F91 Dudelange - Betis Sevilla |
| Olympiakos - Milan |
