| 24/09/2020 |
 Willem II  | - |  Glasgow Rangers0‑4 |
Sporting Portugal  | - |  Aberdeen1‑0 |
Rijeka  | - |  FC Kolos Kovalivka (a.e.t.) 2‑0 |
Sint-Gall  | - |  AEK Athens0‑1 |
Milan  | - |  Bodo/Glimt3‑2 |
Basel  | - |  Anorthosis Famagusta3‑2 |
LASK Linz  | - |  Dunajska Streda7‑0 |
Legia Warsaw  | - |  Drita2‑0 |
Wolfsburg  | - |  Desna2‑0 |
Shkendija  | - |  Tottenham1‑3 |
Granada  | - |  Lokomotivi Tbilisi2‑0 |
Standard  | - |  Vojvodina (a.e.t.) 2‑1 |
Galatasaray  | - |  Hajduk Split2‑0 |
Copenhagen  | - |  Piast Gliwice3‑0 |
Apoel Nicosia  | - |  Zrinjski Mostar (a.e.t.) 2‑2 |
Sarajevo  | - |  Buducnost Podgorica2‑1 |
Sheriff Tiraspol  | - |  Dundalk (a.e.t.) 1‑1 |
Klaksvik  | - |  Dinamo Tbilisi6‑1 |
Steaua Bucharest  | - |  Slovan Liberec0‑2 |
Hapoel Be'er Sheva  | - |  Motherwell3‑0 |
Charleroi  | - |  Partizan Belgrade (a.e.t.) 2‑1 |
Malmö  | - |  NK Lokomotiva5‑0 |
Rosenborg  | - |  Alanyaspor1‑0 |
Besiktas  | - |  Rio Ave (a.e.t.) 1‑1 |
PFC CSKA-Sofia  | - |  B36 Torshavn3‑1 |
Riga FC  | - |  Celtic Glasgow0‑1 |
Djurgårdens  | - |  Cluj0‑1 |
Floriana  | - |  Flora Tallinn (a.e.t.) 0‑0 |
Mura  | - |  PSV1‑5 |
Rostov  | - |  Maccabi Haifa1‑2 |
Videoton  | - |  Reims (a.e.t.) 0‑0 |
Viktoria Plzen  | - |  SonderjyskE3‑0 |
KuPS  | - |  Suduva2‑0 |
Avan Academy  | - |  NK Celje (a.e.t.) 1‑0 |
Avan Academy 
Red Star Belgrade10:00
KuPS12:30
Lech Poznan13:00
Granada13:00
Apoel Nicosia13:00
Viktoria Plzen13:30
Qarabag14:00
Ludogorets14:00
Rijeka14:00
Videoton14:00
Klaksvik14:30
KF Tirana14:30
PFC CSKA-Sofia14:30
Wolfsburg14:45
Galatasaray14:45
LASK Linz15:00
Milan15:00
Tre Fiori1‑0